CXCR4 Antibody – All You Need to Know

CXCR4 is a molecule equipped with potent chemotactic activity for lymphocytes. It is a primary-chemokine receptor (also known as FUSIN or NPY3R) specific for stromal-derived-factor-1 however, it’s also found in a wide variety of cells that work as a coreceptor for HIV. It also assists a cancerous cell to spread. When a person is infected with HIV then this CXCR4 assists and acts in the form of a coreceptor for this virus to enter a host cell and spread. CXCR4 may be the coreceptor for X4 HIV-1 and HIX-2 to gain entry into CD4+ cells however, it can also act as the only receptor for HIV-2 to gain entry to CD4+ cells. CXCR4 also plays a vital role in vascularization of the gastrointestinal tract, hematopoiesis, and cardiac ventricular septum formation.

Generic Nomenclature: chemokine (C-X-C motif) receptor 4

Family: GPCR – Chemokine

Synonyms: CXCR-4, CXCR4, WHIM, CD184, CXC-R4, CD184 antigen, D2S201E, Cmkar4,  FB22, NPY3R, NPYRL, Fusin, NPYY3R, Npyy3, HM89, LCR1, SDF-1 receptor, NPYR, Neuropeptide Y receptor Y3, HSY3RR, Cxc chemokine receptor 4, LESTR,

What is the CXCR4 antibody?

CXCR4 antibody helps block and prevent the CXCR4 receptor from activating and hindering the progression of cancer. The downstream effects of the CXCR4 receptor are the activation of cell movement allowing cancer to spread. The progression or spreading of cancer from its original location is known as metastasis. CXCR4 antibody assists in blocking the cell movement which prevents the growth of cancer cells or from becoming malignant. It’s also being used to prevent the spread of HIV-1 and HIV-2 infected cells. Macrocyclic ligands have been used as a CXCR4 antibody.

Thisantibody has been tested and validated by human, mouse, rat, rabbit, monkey, chimpanzee, orangutan, and few other species of the monkey family.

CXCR4 antibody helps to treat HIV infections, Tumor angiogenesis, Malignant Neoplasm of Breast, Leukemia, Immunologic Deficiency Syndromes, Infective disorder, Virus Diseases, Neoplasm Metastasis, Tissue Adhesions, Acquired Immunodeficiency Syndrome, Carcinoma, Mammary Neoplasms, Neoplasms, Malignant Neoplasms, Cell Invasion, Carcinoma, Malignant Paraganglionic, etc.

There are some publications which were released the details of which are mentioned below:

  • PubMed ID 24912495 (Tacrolimus promotes hepatocellular carcinoma and enhances CXCR4/SDF-1? expression?in vivo)
  • PubMed ID 25471741 (Blockade of CXCL12/CXCR4 signaling inhibits intrahepatic cholangiocarcinoma progression and metastasis via inactivation of canonical Wnt pathway)
  • PubMed ID 18983683 (Chemokine CXCL12 and its receptor CXCR4 expression are associated with perineural invasion of prostate cancer)
  • PubMed ID 25712213 (Macrophage migration inhibitory factor%u2013CXCR4 is the dominant chemotactic axis in human mesenchymal stem cell recruitment to tumors)

CXCR4 antibody specific protocols

  • Western Blottting Resource Center: Western blotting differs from other immunoassays. Western blotting requires samples of solubilized proteins to be denatured and charged with SDS.
  • Immunohistochemistry Resource Center: IHC can accurately detect protein localization. IHC, unlike Western blot or ELISA, does not require that proteins be extracted from cells or tissues.
  • Flow Cytometry Technical Resource Center: Flow cytometry basic principle of operation is fairly simple. The primary requirement of every Flow Cytometry experiment is that the cells under analysis must be in a single-cell suspension.